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One significant limitation of GHK-Cu is its short in vivo half-life of approximately 30 minutes in plasma, combined with the instability of the metal-peptide complex due to copper high reactivity

Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis

A stable structure that binding to HER2 proteins inhibits HER2 degradation, leading to sustained activation of the PI3K-AKT and RAS-MAPK signaling pathways, which contribute to BRCA progression 33

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